Adverse Reactions with Covid-19 Vaccine Booster are of Milder Gravity than with First and Second Dose

 Jose Luis Turabian*

Citation: Turabian JL. Adverse Reactions with Covid-19 Vaccine Booster are of Milder Gravity than with First and Second Dose. Medp Public Health Epidemiol. 2022; 1(1): mpphe–202210005.

Abstract

   Background: It is not clearly known whether the third doses (booster) of the covid-19 vaccine present more or fewer adverse reactions than those of the first and second doses. 

   Objective: Comparison of self-reported adverse reactions, with first and second versus third (booster) doses of covid-19 vaccine. 

   Emplacement: The population attended in a general medicine consultation in Toledo, Spain. 

   Methodology: Analysis of secondary data from two observational, longitudinal, and prospective studies: 1) Adverse covid-19 vaccines reactions from February to July 2021; And 2) Adverse covid-19 vaccines booster reactions from November 2021 to August 2022. 

   Results: We included 21 cases of adverse covid-19 vaccines booster reactions and 109 cases of adverse covid-19 vaccines reactions (1 and 2 doses). Cases of adverse covid-19 vaccines booster reactions versus cases of adverse covid-19 vaccines reactions (1 and 2 doses) differed only statistically significantly in presenting more mild and less severe adverse reactions. 

   Conclusions: In the context of general medicine in Toledo (Spain), there is a tendency for adverse reactions to be significantly lighter with the booster than with the first or second dose of the covid-19 vaccine. 

   Key Words: COVID-19; SARS-CoV-2; Adverse Drug Events; Post-Vaccination Reactions; Booster; COVID-19 vaccine; General Practice; Secondary Analysis