Jose Luis Turabian*
Citation: Turabian JL. Adverse Reactions with Covid-19 Vaccine Booster are of Milder Gravity than with First and Second Dose. Medp Public Health Epidemiol. 2022; 1(1): mpphe–202210005.
Abstract
Background: It is not clearly known whether the third doses (booster) of the covid-19
vaccine present more or fewer adverse reactions than those of the first and second doses.
Objective: Comparison of self-reported adverse reactions, with first and second versus third
(booster) doses of covid-19 vaccine.
Emplacement: The population attended in a general medicine consultation in Toledo,
Spain.
Methodology: Analysis of secondary data from two observational, longitudinal, and
prospective studies: 1) Adverse covid-19 vaccines reactions from February to July 2021; And 2)
Adverse covid-19 vaccines booster reactions from November 2021 to August 2022.
Results: We included 21 cases of adverse covid-19 vaccines booster reactions and 109 cases
of adverse covid-19 vaccines reactions (1 and 2 doses). Cases of adverse covid-19 vaccines
booster reactions versus cases of adverse covid-19 vaccines reactions (1 and 2 doses) differed
only statistically significantly in presenting more mild and less severe adverse reactions.
Conclusions: In the context of general medicine in Toledo (Spain), there is a tendency for
adverse reactions to be significantly lighter with the booster than with the first or second dose
of the covid-19 vaccine.
Key Words: COVID-19; SARS-CoV-2; Adverse Drug Events; Post-Vaccination Reactions;
Booster; COVID-19 vaccine; General Practice; Secondary Analysis
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