Jose Luis Turabian*

Citation: Turabian JL. Adverse Covid-19 Vaccines Booster Reactions Case Series, From November 2021 TO September 2022, In a General Medicine Office in Toledo, Spain. Medp Public Health Epidemiol. 2022; 1(1): mpphe–202210001.

Abstract

   Background: There is lack of clinical outcome data on the safety of covid-19 vaccines booster. 

   Objective: To study, in general medicine, clinical-epidemiological characteristics of patients who consulted for self-reported adverse reactions to covid-19 vaccines booster. 

   Methodology: An observational, longitudinal and prospective case series study of patients with adverse reactions to covid-19 vaccines booster, based on a cohort of patients in a family medicine office in Toledo (Spain) was carried out from November 1, 2021 to September 1, 2022. 

   Results: Twenty-one cases of adverse reactions to covid-19 vaccines booster were included. The mean age of the patients was 45 years. 67% were women. According to the criteria of causality, 42% were probable. According to the time of appearance, the majority (76%) occurred between 1-72 hours after shot. 52% were moderate (with interference with normal activities); there was no severe adverse reaction. 81% of adverse reactions to covid-19 vaccines booster occurred with Moderna mRNA-1273. Only 1 case had also presented an adverse reaction with a previous dose of the vaccine. 71% had chronic diseases, being 21% from the genitourinary group and 17% mental. 64% of the symptoms were from the group of symptoms, signs not elsewhere classified (Injection site pain, throat pain, fever, chills, dizziness, headache, asthenia, lymphadenopathy). 

   Conclusion: In the context of general medicine in Toledo (Spain), during the 10 months following the start of the covid-19 vaccination booster, no serious adverse effects were found, which were mostly symptoms and signs not otherwise specified in middle aged women with chronic diseases of genitourinary and mental system. 

   Key Words: COVID-19; Adverse Drug Events; Post-vaccination Reactions; Booster; COVID-19 vaccine; General Practice; Case Series